Referenced Papers (8)
Painting a new picture of personalised medicine for diabetes
Mark I McCarthy
Diabetologia, 2017
"The speaker uses this paper's 'palette model' to illustrate the heterogeneity of Type 2 Diabetes, explaining that it arises from multiple biological pathways."
High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease
Hyunkyung Kim, Kenneth E Westerman, Kirk Smith, Joshua Chiou, Joanne B Cole, Timothy Majarian
Diabetologia, 2023
"This paper describes a comprehensive list of variants used for generating genetic clusters in various complex diseases, including T2D, CAD, and CKD."
Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots
Saaket Agrawal, Minxian Wang, Marcus D R Klarqvist, Kirk Smith, Joseph Shin, Hesam Dashti
Nat. Commun., 2022
"This paper provided trait GWAS summary statistics for body fat composition, which was used as an input for generating genetic clusters."
Multi-trait genetic analysis reveals clinically interpretable hypertension subtypes
Felix Vaura, Hyunkyung Kim, Miriam S Udler, Veikko Salomaa, Leo Lahti
Circ. Genom. Precis. Med., 2022
"This paper provided trait GWAS summary statistics for hypertension, which was used as an input for generating genetic clusters."
Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots
Saaket Agrawal, Minxian Wang, Marcus D R Klarqvist, Kirk Smith, Joseph Shin, Hesam Dashti
Nat. Commun., 2022
"This paper provided trait GWAS summary statistics for mapping patterns, which was used as an input for generating genetic clusters."
Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes
Magdalena Sevilla-González, Kirk Smith, Ningyuan Wang, Aubrey E Jensen, Elizabeth M Litkowski, Hyunkyung Kim
Nat. Commun., 2025
"This paper provided trait GWAS summary statistics for Fasting Insulin, which was used as an input for generating genetic clusters."
Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis
Miriam S Udler, Jaegil Kim, Marcin von Grotthuss, Sílvia Bonàs-Guarch, Joanne B Cole, Joshua Chiou
PLoS Med., 2018
"This is an early publication on the genetic clustering work from Dr. Udler's lab, showing the initial clusters and methodology."
Multi-ancestry polygenic mechanisms of type 2 diabetes
Kirk Smith, Aaron J Deutsch, Carolyn McGrail, Hyunkyung Kim, Sarah Hsu, Alicia Huerta-Chagoya
Nat. Med., 2024
"This is the most recent publication on the genetic clustering work, showcasing further expansion to multi-ancestry GWAS data."